Polyparazitism consequences and complex antiparazitic treatment (Brovitacoccid, Avomec, Tilozin 200) upon the postvaccin immunity in bovine.

Abstract

The obtained results shows that the polyparasitism (Strongyloides papillosus, Neoascaris vitulorumi, Eimeria bovis, E. smithi, E. zuerni, E. ellipsoidalis) decrease the level of total lymphocytes by 10% (P>0,05), B - 12,6% (P<0,01), T - 18,7% (P<0,01), but increase the quantity of nul lymphocytes by 31,4% (P<0,001) and after all these modifications a lower antibody level is forming 72% (P<0,01) by comparing with the group of uninfected animals and treated with the anticolibacillar vaccine. After the vaccination of the calf treated with Brovitacoccid, Avomec and Tilozin 200 the decreasing of total lymphocyte level was registered 12,5% (P<0,05), B - 16,9% (P<0,001), T - 21,2% (P<0,01), but the quantity of null lymphocytes increased - 21,2% (P<0,01). The impact of this treatment recorded a lower titre of specific anticolibacillar antibodies with 82% (P<0,01) by comparing with the uninfected vaccinated animals. This fact is probably due to the long-term immunotoxic effect of the drug factor, which deeply disturb the biochemical and biophysical processes at the level of immunocompetent cells, including the B lymphocytes that produce the specific antibodies