Abstract
P822 Aims: Our aim was to estimate prospectively the prevalence of BK replication and nephropathy in kidney and pancreas/kidney transplanted at our centre. Methods: 118 kidney or pancreas/kidney recipients transplanted at our centre between 15.05.2001 and 15.04.2003 were included into the study. Patients received different immunosuppressive regimens including steroids, azatioprine, mycophenolate mofetil, cyclosporine, tacrolimus, rapamycyne and in some cases induction treatment. Serum samples were collected at the end of 1, 3, 6, 12 months after transplantation. All samples were analysed using quantitative PCR assay. Graft biopsy was performed in every case of graft function deterioration (serum creatinine level increase >25%) after excluding extrarenal causes. Beside standard histopathological examination all biopsy specimens were stained using immunohistochemisry assay for the presence of polyomavirus specific antigen. Results: BKV DNA was found in 20 (16%) patients in one or more samples. Renal biopsy was performed at least once in 50 patients. BKV nephropathy as assessed by SV 40 staining was found in two patients. Conclusions: Low level BKV replication occurs periodically in as many as 16 % of patients. BK nephropathy is a rare complication at our centre with the incidence of 1,6%.
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