Polyol mediated synthesis of hexagonal manganese cobaltate nanoparticles for voltammetric determination of thioridazine

Abstract

A polyol mediated synthesis method is proposed as a good crystallinity, high sensitivity, and efficient fabrication route to synthesize hexagonal manganese cobaltate nanoparticles (MnCo2O4) using ethylene glycol as a reducing and stabilizing agent. The structural and morphological study was examined by X-ray diffraction (XRD), Raman spectroscopy, fourier transform infrared spectroscopy (FT-IR), X-ray photoelectron spectroscopy (XPS), field emission scanning electron microscopy (FE-SEM), transmission electron microscopy (TEM) with energy-dispersive X-ray spectroscopy (EDX) analysis. The electrocatalytic performance of as-prepared nanoparticles drop cast on the glassy carbon electrode. Under optimized voltammetric conditions, the as-proposed sensor shows good performance towards thioridazine (TZ) oxidation with a linear range from 0.2 to 1119 μM, a low detection limit of 0.021 μM. The fabricated MnCo2O4 electrode sensitivity was calculated to be 1.872 µA µM–1 cm2. The practical applicability of the sensor exhibits good stability, repeatability, reproducibility, and selectivity in the presence of 15-fold concentrations of metal ions and organic compounds for the TZ detection. The real-time analysis of fabricated electrode was applied to detect TZ in human serum samples and gave satisfactory results.