Abstract

New silver(I) complex with thianthrene (tia), [Ag(NO3)(tia)(H2O)]n, was synthesized by the reaction of AgNO3 with an equimolar amount of tia in ethanol/dichloromethane (v/v 1:1) at room temperature, and characterized by NMR, IR and UV-Vis spectroscopy and single-crystal X-ray diffraction analysis. The antimicrobial activity of the synthesized complex was evaluated against the broad panel of Gram-positive and Gram-negative bacteria and Candida spp. This complex showed significant activity toward important human pathogens Gram-positive Staphylococcus aureus and Candida parapsilosis with minimal inhibitory concentrations (MICs) being 3.91 µg/mL. The interaction of [Ag(NO3)(tia)(H2O)]n with calf thymus DNA (ct-DNA) and bovine serum albumin (BSA) was studied to evaluate the binding affinity towards these biomolecules for possible insights on the mode of antimicrobial activity. The binding affinity of the investigated complex to BSA is higher than that for DNA, indicating that proteins could be more favorable binding sites for this complex in comparison to the nucleic acids.

Highlights

  • Silver(I) complexes showed a wide range of applications in medicine as effective antiseptic, antibacterial and anti-inflammatory agents [1]

  • The chemistry of new silver(I) complex with thianthrene, [Ag(NO3)(H2O)(tia)]n, is studied in solution and solid state using spectroscopic and crystallographic methods. This complex was evaluated for its antimicrobial activity against the panel of representative microorganisms, while its cytotoxicity was evaluated against normal human lung fibroblast cell line (MRC-5)

  • Spectroscopic (1H and 13C NMR, IR and UV-Vis), electrochemical and crystallographic methods were applied for the characterization of the synthesized complex

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Summary

Introduction

Silver(I) complexes showed a wide range of applications in medicine as effective antiseptic, antibacterial and anti-inflammatory agents [1]. The critical factor in determining the antimicrobial activity of silver(I) complexes is the type of the ligand donor atom bound to the Ag(I) ion. In this respect, in the last few decades, Proceedings 2020, 4, x; doi: FOR PEER REVIEW www.mdpi.com/journal/proceedings. The chemistry of new silver(I) complex with thianthrene (tia), [Ag(NO3)(H2O)(tia)]n, is studied in solution and solid state using spectroscopic and crystallographic methods. This complex was evaluated for its antimicrobial activity against the panel of representative microorganisms, while its cytotoxicity was evaluated against normal human lung fibroblast cell line (MRC-5). The interaction of [Ag(NO3)(H2O)(tia)]n complex with biologically important molecules, BSA and DNA, was studied by different experimental techniques

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