Abstract
Parchuri and colleagues 1 Parchuri S Mohan S Cunha BA Extended spectrum β-lactamase-producing Klebsiella pneumoniae chronic ambulatory peritoneal dialysis peritonitis treated successfully with polymyxin B. Heart Lung. 2005; 34: 360-363 Summary Full Text Full Text PDF PubMed Scopus (22) Google Scholar recently reported a patient receiving chronic ambulatory peritoneal dialysis who developed peritonitis and bacteraemia due to an extended-spectrum β-lactamase-producing strain of Klebsiella pneumoniae. The infection was not controlled despite removal of the dialysis catheter and treatment for a week with intravenous amikacin and meropenem, although the isolate was intermediately sensitive to these antibiotics. Fortunately, the patient was cured with intravenous administration of polymyxin B. All symptoms, including abdominal pain, improved within 36 h of start of polymyxin B treatment, and the patient became completely asymptomatic 12 h later. This case highlights the renaissance of polymyxins as salvage antibiotics for patients with infections due to multidrug-resistant gram-negative bacteria. 2 Falagas ME Kasiakou SK Colistin: the revival of polymyxins for the management of multidrug-resistant gram-negative bacterial infections. Clin Infect Dis. 2005; 40: 1333-1341 Crossref PubMed Scopus (1218) Google Scholar
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