Abstract
Polymyxin-resistant Acinetobacter spp. isolates: what is next?
Highlights
Sabaté M, Miró E, Navarro F, Vergés C, Aliaga R, Mirelis B, et al Beta-lactamases involved in resistance to broad-spectrum cephalosporins in Escherichia coli and Klebsiella spp. clinical isolates collected between 1994 and 1996, in Barcelona (Spain)
The susceptibility to polymyxin B and meropenem were tested by disk diffusion and agar dilution techniques according to National Committee for Clinical Laboratory Standards (NCCLS) recommendations [9,10]
By using the polymyxin B resistance breakpoint (MIC >4 μg/mL) presented by the former NCCLS document, which was recently validated, we found that five Acinetobacter spp. isolates were considered resistant to polymyxin B (MICs, 8–32 μg/mL) [8,11]
Summary
Performance standards for antimicrobial disk susceptibility test. 7. Sabaté M, Miró E, Navarro F, Vergés C, Aliaga R, Mirelis B, et al Beta-lactamases involved in resistance to broad-spectrum cephalosporins in Escherichia coli and Klebsiella spp. clinical isolates collected between 1994 and 1996, in Barcelona (Spain). To the Editor: In Brazilian hospitals, Acinetobacter spp. has been an important etiologic agent of nosocomial infections, mainly pneumonia [1,2,3]. More toxic agents such as polymyxins have been used as alternative therapeutic drugs against multidrug-resistant Acinetobacter infections [5,6].
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