Abstract
Treatment of Escherichia coli cells with polymyxin B nonapeptide (PMBN) makes them susceptible to valinomycin and A23187 action. The sensitivity of the cells towards these ionophores is enhanced at least 50- or 100-fold, respectively. PMBN/ionophore treatment should make it possible to influence intracellular potassium (K) and magnesium (Mg) concentrations of E. coli in vivo.
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