Abstract
A 53-year-old woman presented with two asymptomatic nodules measuring 35 mm and 10 mm in diameter on the buccal mucosa and upper lip, respectively. Diagnostic hypotheses included salivary gland lesions, and incisional and excisional biopsies were performed in the buccal mucosa and lip. The histopathologic examination revealed malignant neoplasm of the salivary glands with a deceptively uniform appearance, characterized by rounded and polygonal cells with indefinite borders and pale cytoplasm, presenting nuclei of varied morphology. The cells had different growth patterns, predominantly arranged in cords and nests. Both lesions were positive for S-100 and CK7 and negative for SMA. The final diagnosis was polymorphous low-grade adenocarcinoma. The patient underwent surgical resection and radiation therapy. No evidence of recurrence was found at follow-up.
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