Abstract
Polymorphous adenocarcinoma (PAC) represents the second most common malignancy of the minor salivary glands. Uncommonly, intratumoral crystalloid deposits may be visualized in PAC. The main types include tyrosine-rich, collagenous, and amylase crystalloids. Here, we reported a case of a 49-year-old black female who was referred complaining of swelling on the hard palate. Clinically, a nodular lesion was observed measuring 4 cm in greater diameter, well-delimited, asymptomatic, and covered by normal-appearing oral mucosa, with time of evolution of 2 years. After incisional biopsy, microscopic examination revealed low-grade PAC containing foci of tyrosine-rich crystalloid deposits. Immunohistochemical analysis revealed positivity for CK AE1/3, CK7, vimentin, α-smooth muscle actin, and Bcl-2, S100, and focally for p53, GFAP, and CD10. The patient was referred to a reference service for treatment, and there has been no evidence of recurrence after 8 months’ of follow-up.
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