Abstract
ObjectiveLow serum 25(OH)D levels are associated with cardiovascular risk factors, and also predict future myocardial infarction (MI), type 2 diabetes (T2DM), cancer and all-cause mortality. Recently several single nucleotide polymorphisms (SNPs) associated with serum 25-hydroxyvitamin D (25(OH)D) level have been identified. If these relations are causal one would expect a similar association between these SNPs and health.MethodsDNA was prepared from subjects who participated in the fourth survey of the Tromsø Study in 1994–1995 and who were registered with the endpoints MI, T2DM, cancer or death as well as a randomly selected control group. The endpoint registers were complete up to 2007–2010. Genotyping was performed for 17 SNPs related to the serum 25(OH)D level.ResultsA total of 9528 subjects were selected for genetic analyses which were successfully performed for at least one SNP in 9471 subjects. Among these, 2025 were registered with MI, 1092 with T2DM, 2924 with cancer and 3828 had died. The mean differences in serum 25(OH)D levels between SNP genotypes with the lowest and highest serum 25(OH)D levels varied from 0.1 to 7.8 nmol/L. A genotype score based on weighted risk alleles regarding low serum 25(OH)D levels was established. There was no consistent association between the genotype score or individuals SNPs and MI, T2DM, cancer, mortality or risk factors for disease. However, for rs6013897 genotypes (located at the 24-hydroxylase gene (CYP24A1)) there was a significant association with breast cancer (P<0.05).ConclusionOur results do not support nor exclude a causal relationship between serum 25(OH)D levels and MI, T2DM, cancer or mortality, and our observation on breast cancer needs confirmation. Further genetic studies are warranted, particularly in populations with vitamin D deficiency.Trial RegistrationClinicalTrials.gov NCT01395303
Highlights
Vitamin D is an ancient hormone with indisputable importance in calcium and bone metabolism
In previous reports from the Tromsø Study we have found low serum 25-hydroxyvitamin D (25(OH)D) levels to be strongly related to hypertension [2], obesity [3], elevated glycated haemoglobin (HbA1c) [4] and an unfavourable serum lipid profile [5]. In line with this we have found low serum 25(OH)D levels to be associated with the risk of developing type 2 diabetes mellitus (T2DM) [6] as well as with increased all-cause mortality [7]
4175 were included as control cohort, 2025 subjects were registered with the endpoints myocardial infarction (MI), 1092 with T2DM, 2924 with cancer and 3828 had died (Table 1)
Summary
Vitamin D is an ancient hormone with indisputable importance in calcium and bone metabolism. In previous reports from the Tromsø Study we have found low serum 25-hydroxyvitamin D (25(OH)D) levels (which is the vitamin D metabolite used to evaluate a subject’s vitamin D status) to be strongly related to hypertension [2], obesity [3], elevated glycated haemoglobin (HbA1c) [4] and an unfavourable serum lipid profile [5]. In line with this we have found low serum 25(OH)D levels to be associated with the risk of developing type 2 diabetes mellitus (T2DM) [6] as well as with increased all-cause mortality [7]. Whether there is a causal relation between low serum 25(OH)D and disease is uncertain and awaits the results of properly performed randomized clinical trials (RCT)
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
