Abstract
Vitamin D receptor (VDR) gene polymorphisms have been reported to increase susceptibility to some malignant tumors, yet the effect on gastric cardiac adenocarcinoma susceptibility remains unknown. Here, we conducted a hospital-based case-control study to examine the correlation of single nucleotide polymorphisms of VDR rs2107301T>C, rs2228570C>T, rs1989969C>T and rs11568820 G>A and gastric cardiac adenocarcinoma susceptibility. A total 330 cases and 608 controls were enrolled in the study. Using ligation detection reaction, we found that the variant alleles of the four polymorphisms were not associated with risk of gastric cardiac adenocarcinoma. Further stratified analyses showed that there was an increased risk associated with VDR rs1989969 polymorphism among patients who were drinking or aged <60. The haplotypes VDR Trs2107301Trs2228570Crs1989969Grs11568820 reduced the susceptibility. This study demonstrated that VDR rs1989969 polymorphism was involved in the carcinogenesis of gastric cardiac adenocarcinoma, especially increased the risk in the younger and alcohol drinking Chinese population.
Highlights
Gastric cardia adenocarcinoma (GCA) remains one of the most common malignant tumor worldwide[1]
We have investigated the correlation of four single-nucleotide polymorphisms (SNPs) Vitamin D receptor (VDR) rs11568820 G>A, VDR rs1989969 C>T, VDR rs2107301 T>C and VDR rs2228570 C>T with esophageal squamous cell carcinoma development, and found that VDR rs2107301 T>C polymorphism with alcohol drinking enhanced the risk of esophageal squamous cell carcinoma[13]
By multivariable logistic analysis, we demonstrated that there was no significant association between the polymorphisms of VDR rs11568820 G>A, rs1989969 C>T, rs2107301 T>C andrs2228570 C>T and the risk of GCA in Chinese population
Summary
Gastric cardia adenocarcinoma (GCA) remains one of the most common malignant tumor worldwide[1]. The etiology of GCA comprises interactions of multiple environmental and genetic factors. Environmental factors including cigarette smoking and alcohol consumption[3, 4], as well as genetic factors such as gene polymorphisms, have been implicated with GCA. The antineoplastic effect of 1,25(OH)2D3 requires the expression of VDR in tumor cells[6]. Increased tumor VDR expression is associated with a better prognosis in various types of cancer[7, 8]. The association of single nucleotide polymorphisms (SNPs) in VDR
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