Polymorphisms of the IL27 gene in a Chinese Han population complicated with pre-eclampsia.

Bin Liu,Lei Zhao,Shiguo Liu,Liqin Wang,Yuan Yao,Miaomiao Xin,Hua Li,Jizheng Lin,Hongda Liang,Yuan Li

doi:10.1038/srep23029

Abstract

IL-27 could inhibit the development of Th17 cells, and the Th17/regulatory T-cell imbalance may reverse maternal tolerance in pre-eclampsia (PE). The aim of this study was to investigate the association between genetic polymorphisms in IL27 with PE. Three SNPs in IL27 (rs153109, rs17855750, and rs181206) were genotyped in a Chinese Han cohort of 1040 PE patients and 1247 normal pregnant women using the TaqMan allelic discrimination real-time PCR method. The CC genotypic distribution of rs153109 was significantly higher among cases than controls (19.1% versus 13.3%, odds ratio [OR]: 1.54, 95% confidence interval [CI]: 1.23–1.93, p < 0.001), and the CT genotype was found to be significantly lower in cases than controls (41.7% versus 49.0%, OR: 0.74, 95% CI: 0.63–0.88, p < 0.001), disputing existing reports indicating the allele frequency of rs153109 is not significantly different between PE patients and controls. Additionally, the CC genotype of rs153109 was significantly more prevalent in PE cases than controls using a recessive model (p < 0.001). The allelic and genotypic frequencies of rs17855750 and rs181206 were not significantly different between two groups. Our results reveal that IL27 polymorphisms may be involved in the development of PE in Chinese Han population.

Highlights

Genotypic test studies suggests that PE has a heritable component, and genetic involvement plays an important role in its development[10]
Considering that IL27 polymorphisms might influence the susceptibility, severity, and outcome of PE15, the purpose of study here was to investigate the correlation between IL27 polymorphisms and the clinical implication of PE in a Chinese Han population, to illustrate whether these SNPs were involved in the development of PE
The demographics such as age, age of menarche, and triglyceride levels were similar between the cases and controls

Summary

Introduction

Genotypic test studies suggests that PE has a heritable component, and genetic involvement plays an important role in its development[10]. Several studies have indicated that many candidate cytokine genes, such as IL10, IL6, TNF-α, and TGF-β1, are thought to be associated with the susceptibility of PE11–14. Considering that IL27 polymorphisms might influence the susceptibility, severity, and outcome of PE15, the purpose of study here was to investigate the correlation between IL27 polymorphisms (rs153109, rs17855750, and rs181206) and the clinical implication of PE in a Chinese Han population, to illustrate whether these SNPs were involved in the development of PE

Objectives

Methods

Results

Conclusion