Abstract
Background: Hyperuricemia is a pathological condition associated with risk factors of cardiovascular disease. In this study, three genetic polymorphisms were genotyped as predisposing factors of hyperuricemia. Methods: A total of 860 Mexicans (129 casesand 731 controls) between 18 and 25 years of age were genotyped for the ABCG2(Q191K), SLC22A12(517G>A), and XDH(518T>C) polymorphisms, as predisposing factors of hyperuricemia. Biochemical parameters were measured by spectrophotometry, while genetic polymorphisms were analyzed by real-time PCR. An analysis of the risk of hyperuricemia in relation to the variables studied was carried out using a logistic regression. Results: Male sex, being overweight or obese, having hypercholesterolemia or having hypertriglyceridemia were factors associated with hyperuricemia ( p ≤ 0.05). The ABCG2 polymorphism was associated with hyperuricemia (OR = 2.43, 95% CI: 1.41-4.17, p = 0.001) and hypercholesterolemia (OR = 4.89, 95% CI: 1.54-15.48, p = 0.003), employing a dominant model, but only in male participants. Conclusions: The ABCG2(Q191K) polymorphism increases the risk of hyperuricemia and hypercholesterolemia in young Mexican males.
Highlights
Hyperuricemia is a pathological condition associated with risk factors of cardiovascular disease
Medians and genotypic distribution between hyperuricemic and normouricemic participants were analyzed using the MannWhitney U test, finding differences for sex, Body Mass Index (BMI), systolic and diastolic pressure, triglycerides, total cholesterol, and low-density lipoprotein cholesterol (LDL-C) (p =
In this study, we found that the ABCG2 (Q191K) polymorphism increases the risk of hyperuricemia as well as of hypercholesterolemia in young Mexican males
Summary
Hyperuricemia is a pathological condition associated with risk factors of cardiovascular disease. Three genetic polymorphisms were genotyped as predisposing factors of hyperuricemia. Methods: A total of 860 Mexicans (129 cases and 731 controls) between 18 and 25 years of age were genotyped for the ABCG2 (Q191K), SLC22A12 (517G>A), and XDH (518T>C) polymorphisms, as predisposing factors of hyperuricemia. Results: Male sex, being overweight or obese, having hypercholesterolemia or having hypertriglyceridemia were factors associated with hyperuricemia ( p ≤ 0.05). The ABCG2 polymorphism was associated with hyperuricemia (OR = 2.43, 95% CI: 1.41-4.17, p = 0.001) and hypercholesterolemia (OR = 4.89, 95% CI: 1.54-15.48, p = 0.003), employing a dominant model, but only in male participants. Conclusions: The ABCG2 (Q191K) polymorphism increases the risk of hyperuricemia and hypercholesterolemia in young Mexican males
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