Abstract
Telomerase reverse transcriptase (TERT) and cleft lip and palate trans-membrane 1 like (CLPTM1L) genes located on chromosome 5p15.33 are known to influence the susceptibility to various cancers. Here, we examined the association of TERT and CLPTM1L single nucleotide polymorphisms (SNPs) with hepatocellular carcinoma (HCC). Genotyping of TERT SNP rs2736098 and CLPTM1L SNP rs401681 was performed using TaqMan allelic discrimination assays in a case-control study of 201 HCC cases and 210 controls in a Chinese male population. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using logistic regression analyses. Both the rs2736098 T allele of TERT and the rs401681 T allele of CLPTM1L were associated with a significantly increased risk of HCC (adjusted odds ratio [OR]=1.605, 95% confidence interval [CI]=1.164-2.213; adjusted OR=1.399, 95%CI=1.002-1.955, respectively). Individuals carrying both TERT and CLPTM1L risk genotypes had an even higher risk of HCC (adjusted OR=4.420, 95%CI= 2.319-8.425). The TERT rs2736098 T allele was also significantly associated with the level of the HCC clinical indicator alpha-fetoprotein (P=0.026). Our results show that genetic variants of TERT and CLPTM1L may contribute to HCC susceptibility in Chinese males.
Highlights
Primary liver cancer is the fifth most commonly diagnosed cancer worldwide but the second most frequent cause of death in men
No other significant associations were observed between the two single nucleotide polymorphisms (SNPs) and cancer progress. This case-control study explored the association of the Telomerase reverse transcriptase (TERT)-cleft lip and palate trans-membrane 1 like (CLPTM1L) region with risk of hepatocellular carcinoma (HCC)
Both TERT rs2736098 and CLPTM1L rs401681 polymorphisms showed a significant association with risk of HCC in a Chinese male population, and significant multiplicative interactions were observed between the two SNPs in the development of HCC
Summary
Primary liver cancer is the fifth most commonly diagnosed cancer worldwide but the second most frequent cause of death in men In women, it is the seventh most commonly diagnosed cancer and the sixth leading cause of cancer death. Results: Both the rs2736098 T allele of TERT and the rs401681 T allele of CLPTM1L were associated with a significantly increased risk of HCC (adjusted odds ratio [OR]=1.605, 95% confidence interval [CI]=1.164-2.213; adjusted OR=1.399, 95%CI=1.002-1.955, respectively). Individuals carrying both TERT and CLPTM1L risk genotypes had an even higher risk of HCC (adjusted OR=4.420, 95%CI= 2.319-8.425). Conclusions: Our results show that genetic variants of TERT and CLPTM1L may contribute to HCC susceptibility in Chinese males
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