Polymorphisms of genes associated with psycho-emotional deviations in a sample of healthy male conscripts

Abstract

The prevalence of candidate gene polymorphic alleles associated with personality disorders was studied in a sample of healthy male Military Innovation Technopolis ERA recruits, science mouth operators of Caucasian race aged 2327 (median age 24). Genotyping of 10 studied polymorphic variants of genes was carried out using polymerase chain reaction in real time. According to the results, the distribution of genotypes in the studied group of single nucleotide polymorphisms corresponded to HardyWeinberg equilibrium, except for the C677T MTHFR variant (rs1801133). The occurrence of minor alleles was as follows: 0.500 for A1438G and 0.310 for C102T (HTRA2); 0.175 for G-6A (CNTF); 0.508 for C T (UCP2); 0.270 for A1298C and 0.325C677T (MTHFR); 0.278A2756G (MTR); 0.571A66G (MTRR); 0.381Alu Ins/Del (ACE); 0.294G1444A (PPARGC1A). In the studied sample, the frequency of occurrence of minor alleles of 10 genetic markers correlated with data collected on people of European descent. The greatest statistical deviation was observed by comparison with data on people of African descent. Statistically significant concordances with different populations and studies conducted in them are the basis for including the selected polymorphisms in a candidate list of psycho-emotional and neurological pathologies influencing the occupational fitness of servicepersons. However, reliable data on the association between mental disorders and the development of degenerative disorders are not available simultaneously in all populations; therefore, additional research is required on this subject.