Abstract
BackgroundCoronary artery disease (CAD) is a leading cause of mortality in many countries. Considerable studies have been carried out to investigate the relationship between the C242T and A640G polymorphisms of CYBA gene and CAD, but the results were still inconsistent. Hence we conducted a meta-analysis to clarify the association.Methods and ResultsA total of 21 eligible literatures were included in the meta-analysis. We observed a significant decreased risk of CAD for C242T polymorphism in Asian population under an allelic model (OR 0.75; 95% CI 0.67–0.84) and a dominant model (OR 0.69; 95% CI 0.61–0.79), however, in overall population and other population no significant association was revealed. We also found A640G polymorphism may contribute to reducing CAD risk under an allelic model (OR 0.84; 95% CI 0.75–0.93), dominant model (OR0.77; 95% CI 0.64–0.92) and recessive model (OR0.82; 95% CI 0.69–0.97). No publication bias was found.ConclusionOur meta-analysis confirmed a protective effect of C242Tpolymorphism on CAD in Asian population and indicated that A640G polymorphism was significantly associated with decreased risk of CAD.
Highlights
Coronary artery disease (CAD), namely ischemic heart disease (IHD) or coronary heart disease (CHD), mainly including angina and myocardial infarction (MI), is still a leading cause of mortality in many countries with three-fourths of global deaths due to CAD in the low- and middle-income countries [1]
Our meta-analysis confirmed a protective effect of C242Tpolymorphism on CAD in Asian population and indicated that A640G polymorphism was significantly associated with decreased risk of CAD
Evidence over recent years has indicated that the predominant cellular source of superoxide anion in the context of cardiovascular diseases is the NADPH oxidase family [8,9], which is a class of membrane-associated enzymes that catalyzes the one electron reduction of oxygen to produce reactive oxygen species (ROS) using NADH or NADPH as the electron donor [10]
Summary
Coronary artery disease (CAD), namely ischemic heart disease (IHD) or coronary heart disease (CHD), mainly including angina and myocardial infarction (MI), is still a leading cause of mortality in many countries with three-fourths of global deaths due to CAD in the low- and middle-income countries [1]. Evidence has shown that oxidative stress contributes to the development of cardiovascular diseases by vascular wall remodeling and endothelial dysfunction [7]. Evidence over recent years has indicated that the predominant cellular source of superoxide anion in the context of cardiovascular diseases is the NADPH oxidase family [8,9], which is a class of membrane-associated enzymes that catalyzes the one electron reduction of oxygen to produce reactive oxygen species (ROS) using NADH or NADPH as the electron donor [10]. Among the components of NADPH oxidase, the p22phox protein, an essential subunit for the activation of the NADPH oxidase [11], is expressed in various cells such as human endothelial cells and vascular smooth muscle cells [12]. Coronary artery disease (CAD) is a leading cause of mortality in many countries. We conducted a meta-analysis to clarify the association
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