Abstract
This study aimed to investigate the possible association between diabetes susceptibility gene transcription factor 7-like 2 (TCF7L2) and gestational diabetes mellitus (GDM) in a Chinese Han population. A total of 556 GDM patients and 500 Non-GDM were included. Eighteen single nucleotide polymorphisms (SNPs) were evaluated. Fifteen tag SNPs were selected from HapMap CHB database with a minor allele frequency of >0.2 and r2 of >0.8. Three additional SNPs were also chosen because these SNPs are associated with type 2 diabetes in East Asians. TCF7L2 rs290487, rs6585194, and rs7094463 polymorphisms were found to be significantly associated with GDM. In multivariate analysis, rs290487 genetic variation (OR = 2.686 per each C allele, P = 0.002), pre-BMI > 24 kg/m2 (OR = 1.592, P = 0.018), age > 25 years (OR = 1.780, P = 0.012) and LDL-C > 3.6 mmol/L (OR = 2.034, P = 0.009) were identified as independent risk factors of GDM, rs7094463 genetic variation (OR = 0.429 per each G allele, P = 0.005) was identified as independent protect factor of GDM. This finding suggests that TCF7L2 rs290487, and rs7094463 were a potential clinical value for the prediction of GDM.
Highlights
Evaluate the association between TCF7L2 and Gestational diabetes mellitus (GDM) in a Chinese Han population, especially because there had some unique characteristics in Chinese Han diabetic population[15]: Rapid growth of incidence of diabetes mellitus, more higher in post plasma glucose compared to increased fast plasma glucose, rapidly progressive failure of pancreatic islet beta cell in Han population compared to Western populations, growing number of elderly pregnant women, lower body mass index with mild insulin resistance
Pre-BMI, BMI, SBP, DBP, fasting plasma glucose (FPG), 1h-PPG, 2h-PPG, Fins, HbA1c, TG, total cholesterol (TCH), and low-density lipoprotein cholesterol (LDL-C), Homeostatic model assessment (HOMA)-IR and 3h-area under the curve (AUC) of insulin were significantly higher in the GDM group than in the NonGDM group (P < 0.001); by contrast, high-density lipoprotein cholesterol (HDL-C), Homeostasis model assessment of beta-cell function (HOMA-B) was significantly lower in the GDM group than in the Non-GDM group (P < 0.001)
GDM prevalence increases fast in China, we screened 3,210 Chinese pregnant women and 556 of those participants were diagnosed with GDM, GDM incidences has increased by 17.3% compared with previously reported data of epidemiological surveys (5% to 10%)
Summary
Evaluate the association between TCF7L2 and GDM in a Chinese Han population, especially because there had some unique characteristics in Chinese Han diabetic population[15]: Rapid growth of incidence of diabetes mellitus, more higher in post plasma glucose compared to increased fast plasma glucose, rapidly progressive failure of pancreatic islet beta cell in Han population compared to Western populations, growing number of elderly pregnant women, lower body mass index with mild insulin resistance.
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