Abstract
BackgroundEstrogen receptors play an important role in mediating estrogen action on target tissues, and the estrogen is relevant to male infertility. Single nucleotide polymorphisms (SNPs) in estrogen receptors may be associated with the risk of male infertility. A variety of case control studies have been published evaluating this association. However, the accumulated studies have shown inconsistent conclusions.MethodsTo further determine the potential association between the four common SNPs (rs2234693, rs9340799, rs1256049 and rs4986938) in estrogen receptors gene and male infertility, this meta-analysis was performed according to the 10 published case control studies. The odds ratio (OR) and 95% confidence interval (CI) were used to evaluate the strength of the associations.ResultsIt was revealed that the sub-group analysis by the ethnicity, for the rs2234693, a significant association in the comparison of CC vs. TT (OR = 0.61, 95% CI: 0.40-0.93), CT vs. TT (OR = 0.67, 95% CI: 0.49-0.93) and CC + CT vs. TT (OR = 0.66, 95% CI: 0.49-0.89) in the Asian population with male infertility. For rs9340799 polymorphism, increased risks were observed for the comparison of AA vs. GG (OR = 1.75, 95% CI: 1.15-2.68) and AA vs. GA + GG (OR = 1.38, 95% CI: 1.02-1.88). For rs1256049 polymorphism, the comparison of the GA vs. GG (OR = 1.52, 95% CI: 1.00-2.31) and AA + GA vs. GG (OR = 1.74, 95% CI: 1.03-2.94), also increased risks present in Asian and Caucasian population, respectively.ConclusionsThe rs2234693C allele was associated with the decreased risk for male infertility; however, the rs9340799AA genotype and the rs1256049GA genotype were associated with an increased risk for male infertility.Electronic supplementary materialThe online version of this article (doi:10.1186/1477-7827-12-79) contains supplementary material, which is available to authorized users.
Highlights
Estrogen receptors play an important role in mediating estrogen action on target tissues, and the estrogen is relevant to male infertility
For rs9340799 polymorphism, increased risks were observed for the comparison of AA vs. GG and AA vs. GA + GG
The results indicated that rs2234693C allele was associated with decreased risk of the male infertility, in the Asian population
Summary
Estrogen receptors play an important role in mediating estrogen action on target tissues, and the estrogen is relevant to male infertility. Single nucleotide polymorphisms (SNPs) in estrogen receptors may be associated with the risk of male infertility. Leydig cells and reduce Sertoli cell numbers in adult when they are given during development [8,9]. The estrogens can disrupt fetal Leydig cell development, inhibit apoptosis of human postmeiotic germ cells, and increase spermatogonial number per testis [8,9,10,11,12]. ERs are members of the nuclear receptor (NR) superfamily that mediates the pleiotropic effects of estrogen in a diverse range of developmental and physiological processes, playing an important role in mediating estrogen action on target tissues [13,14]
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