Polymorphisms in chronic rhinosinusitis with nasal polyps – a systematic review

Vanessa Ramos Pires Dinarte,Anemari Ramos Dinarte Dos Santos,Luiza Ferreira De Araújo,Mariah Guieiro Alves Dos Reis,Edwin Tamashiro,Fabiana Cardoso Pereira Valera,Wilson Araújo Da Silva Júnior,Wilma Terezinha Anselmo-Lima

doi:10.1016/j.bjorl.2017.03.002

Abstract

IntroductionChronic rhinosinusitis with nasal polyps is a multifactorial disease with a complex pathophysiology involving multiple genetic and environmental factors. ObjectiveThe purpose of this work review is to focus on the importance of genetic studies in chronic rhinosinusitis with nasal polyps besides the several barriers that exists for its understanding. MethodsA systematic review on studies of association between single nucleotide polymorphisms and chronic rhinosinusitis with nasal polyps based on a PubMed/Medline and Periódicos CAPES search of all articles published between January 2005 and January 2015 was made. The search was guided on studies containing the terms polymorphisms, rhinosinusitis, and polyps. ResultsTwo studies found an association of MMP-9 and MMP-2 polymorphisms and chronic rhinosinusitis with nasal polyps, but not in patients with recurrent nasal polyps. Other studies found an association of nasal polyps with MMP-9 polymorphisms, but not with MMP-2 ones. There is evidence of an association of LTC4S, NOS2A, PTGDR, MET, COX-2, OSF-2, and LF polymorphisms and the risk of developing nasal polyps, especially when combined with chronic allergic rhinitis and asthma. ConclusionGenetic studies on chronic rhinosinusitis with nasal polyps are promising and may offer insights into its pathophysiology, which is likely affected by multiple genetic factors.

Highlights

Chronic rhinosinusitis with nasal polyps is a multifactorial disease with a complex pathophysiology involving multiple genetic and environmental factors
Studies that only evaluated patients with aspirin-exacerbated respiratory disease, cystic fibrosis, Epstein---Barr virus, asthma and studies that grouped together Chronic Rhinosinusitis (CRS) patients with and without nasal polyps were excluded
In a study conducted in Taiwan, Wang et al (2008) investigated the role of 17 Matrix Metalloproteinase-2 (MMP-2) Single Nucleotide Polymorphisms (SNPs) in the development of CRSwNP using three models of genetic inheritance

Summary

Introduction

Chronic rhinosinusitis with nasal polyps is a multifactorial disease with a complex pathophysiology involving multiple genetic and environmental factors. Objective: The purpose of this work review is to focus on the importance of genetic studies in chronic rhinosinusitis with nasal polyps besides the several barriers that exists for its understanding. Methods: A systematic review on studies of association between single nucleotide polymorphisms and chronic rhinosinusitis with nasal polyps based on a PubMed/Medline and Periódicos. ଝ Please cite this article as: Dinarte VR, Santos AR, Araújo LF, Reis MG, Tamashiro E, Valera FC, et al Polymorphisms in chronic rhinosinusitis with nasal polyps --- a systematic review. Additional symptoms include endoscopic signs of Nasal Polyps (NP), and/or mucopurulent discharge primarily from middle meatus, and/or edema/mucosal obstruction in middle meatus. According to a study performed within the Global Allergy and Asthma European Network (GA2LEN), the overall prevalence of Chronic Rhinosinusitis (CRS) in Europe was 10.9%.2. These figures are within the estimated global prevalence of the condition, which affects 5%---15% of the general population.[1]

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