Abstract
Prevalence of CCR5Δ32 among blood samples of more than 400 healthy and HIV-1-infected people was investigated in Iran. Polymerase chain reaction (PCR) following DNA extraction was used. Desired frequency was analyzed by Hardy–Weinberg equilibrium (HWE) analysis and SPSS 16.0 software to harvest the results. The prevalence of CCRΔ32 heterozygote genotype was 3% in healthy people and 0.7% in HIV-1–infected individuals. There was no homozygote CCR5Δ32 in both groups, and the allele Δ32 was only observed in 1.5% and 0.36% of healthy and HIV-1–infected participants, respectively. Therefore according to this study, the frequency of the allele CCR5Δ32 indicates no significant difference between either groups (p = 0.18) and it sounds that the mentioned mutation in heterozygote people would not affect their susceptibility against HIV infection. Genotyping trial in Iranians with HIV infection is supposed to be helpful as a matter of prognostic purposes.
Highlights
Acquired immunodeficiency syndrome (AIDS) was initially diagnosed as an emerging disease in 1981
According to the recent Iranian official report, 28,663 individuals are infected with human immunodeficiency virus (HIV) while 6435 of them are struggling with AIDS. 1,800,000 people are living in Golestan Province, southeast of Caspian Sea
These samples were stored at −20°C along with one hundred forty blood samples which were simultaneously collected from HIV-1-infected individuals in the clinics of Golestan University of Medical Sciences, Iran
Summary
Acquired immunodeficiency syndrome (AIDS) was initially diagnosed as an emerging disease in 1981. A retrovirus, named human immunodeficiency virus (HIV), is known to cause AIDS, and the lack of an efficient vaccine against it has made this virus as one of the most destructive complications in the world [1]. According to The Joint United Nations Programme on HIV/AIDS (UNAIDS), about 36.7 million people (34 to 39.8 million) have been suffering from HIV infection in the world by 2015. According to the recent Iranian official report, 28,663 individuals are infected with HIV while 6435 of them are struggling with AIDS. 1,800,000 people are living in Golestan Province, southeast of Caspian Sea. Of these, 194 people are suffering AIDS. The positive role of different genes in AIDS progression has still remained controversial [2]
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