Polymorphisms in Acute Coronary Syndrome

Abstract

Background: Because of their effects on inflammatory processes, some genes are candidates for association with Acute Coronary Syndrome (ACS). While a relationship between Single Nucleotide Polymorphisms (SNP) and ACS has been suggested in some populations, but not in others, genotype characterization of genes related to inflammatory reactions, becomes necessary for specific populations. Aim: In this study, we evaluate IL6 (rs1800795), LEPR (rs6700896) and IL1b (rs16944) SNPs in a healthy population and compare the frequencies with other populations to characterize them in a region of Brazil and investigate the role of SNPs as prognostic markers in the development of ACS in futures studies. Methods: IL6, LEPR and IL1b genes were genotyped in 295 blood donors from Fundacao de Hematologia e Hemoterapia de Pernambuco. Genotyping was carried out by polymerase chain reaction, followed by DNA sequencing or enzymatic cleavage. G Williams test and odds ratio with confidence intervals of 95% were used. The significance value was p Results: There was no difference in genotype distribution between gender or age groups. Genotypic and allelic frequencies were similar between Brazilian populations but different from most other population’s analyzed (p Conclusions: Genotypic characterization of genes that can influence the development of ACS is important, since it can provide a tool for future studies in the use of genetic markers in prevention and diagnosis of diseases. Keywords : Acute Coronary Syndrome; Blood Donors; Prognostic Markers; Polymerase Chain Reaction; Single Nucleotide Polymorphisms