Polymorphisms FTO rs9939609, PPARG rs1801282 and ADIPOQ rs4632532 and rs182052 but not lifestyle are associated with obesity related-traits in Mexican children.

C Muñoz-Yáñez,R Pérez-Morales,E Calleros-Rincón,R A González,G Ballesteros,J Espinosa,H Moreno-Macías

doi:10.1590/1678-4685-gmb-2015-0267

Abstract

Concerning the genetic factors of obesity, no consistent association between populations has been reported, which may be due to the frequency of polymorphisms, the lifestyle of studied populations and its interaction with other factors. We studied a possible association of polymorphisms FTO rs9939609, PPARG rs1801282, and ADIPOQ rs4632532 and rs182052 with obesity phenotypes in 215 Mexican children. Glucose, triglycerides, cholesterol, HDL and LDL were measured. In addition, weight, height, waist circumference and triceps skin thickness were recorded. High-energy diets and sedentary behavior were evaluated with a validated questionnaire. In contrast with other reports, only FTO rs9939609 was associated with obesity related-traits, including BMI (p = 0.03), waist circumference (p = 0.02), triceps skinfold (p = 0.03) and waist/height ratio (p = 0.01), and also with cholesterol levels (p = 0.02) and LDL (p = 0.009). Lower levels of triglycerides (p=0.04) were related with presence of PPARG rs1801282, while ADIPOQ rs4632532 showed an effect on HDL (p = 0.03) levels. On the other hand, diet, physical activity and screen time were not related with obesity. In summary, only FTO rs9939609 was associated with obesity related-traits, while PPARG2 rs1801282 and ADIPOQ rs4632532 were involved in lipid metabolism.

Highlights

Obesity is a worldwide public health problem due to its association with chronic diseases, such as type 2 diabetes, hypertension, cardiovascular disorders and certain types of cancer
We investigated the association between polymorphisms FTO rs9939609, PPARG2 rs1801282, and ADIPOQ rs4632532 and rs182052 with obesity-related traits in a Mexican population with high prevalence of childhood obesity
The prevalence of overweight/obesity in the 215 evaluated children was 43.72% and 39.07% based in the International Obesity Task Force (IOTF) and WHO cutoffs, respectively (Table 1); no significant difference was observed in the association analysis using the different cutoffs

Summary

Introduction

Obesity is a worldwide public health problem due to its association with chronic diseases, such as type 2 diabetes, hypertension, cardiovascular disorders and certain types of cancer. FTO functions are not yet fully described; an in vitro study showed that it acts as a co-activator of the C/EBP family of transcriptional regulators, which in conjunction with PPARG are necessary for adipocyte differentiation (Wu et al, 2010). It is expressed in proopiomelocortin-producing neurons participating in the satiety cycle (Tung et al, 2010). We investigated the association between polymorphisms FTO rs9939609, PPARG2 rs1801282, and ADIPOQ rs4632532 and rs182052 with obesity-related traits in a Mexican population with high prevalence of childhood obesity

Materials and Methods

Results

Discussion