Abstract
Objective To evaluate the association of single nucleotide polymorphisms (SNPs) in the genes/loci IRF6, WNT3 A, GSK3 B, 8 q24, and WNT11, representing regions consistently altered in nonsyndromic oral clefts with breast and oral cancers in the Brazilian population. Study Design We performed a case-control study with association of SNPs rs642961 (IRF6), rs708111 (WNT3 A), rs9879992 (GSK3 B), rs987525 (8 q24), and rs1533767 (WNT11) in 159 samples from breast cancer patients and 79 patients with oral squamous cell carcinoma. A total of 121 female controls (breast controls) and 130 oral cancer controls were used. Logistic regression analysis was used to adjust for confounding factors. A value of P Results Although our results have not demonstrated association between frequencies of SNP genotypes in IRF6, WNT3 A, GSK3 B, 8 q24, and WNT11 and the risk of breast and oral cancers, gene-gene interactions were associated. Conclusion Our data revealed an association between gene-gene interactions in IRF6, WNT3 A, GSK3 B, 8 q24, and WNT11 at risk of breast cancer and oral squamous cell carcinoma in a Brazilian population. Additional experiments and large-scale independent studies in other ethnic populations are needed to confirm our results.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
