Abstract

Aims: Folate supplementation appears to reduce colorectal cancer (CRC) risk. CRC risk is also modulated by the C to T polymorphism at position 677 of the methylenetetrahydrofolate reductase (MTHFR) gene which results in a thermolabile variant of MTHFR and is associated with reduced cellular folate levels. We looked for a relationship between MTHFR expression in colorectal tumour tissue and the C677T polymorphism.

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