Abstract
Adiponectin (ADIPOQ) plays a critical role in energy and lipid metabolism, indicating that adiponectin could affect livestock productivity. There is an association between polymorphisms in the ADIPOQ gene and variations in livestock productive traits. Therefore, this study investigated the relationship between ADIPOQ polymorphism and productive traits in Awassi ewes. This study included 200 sexually mature ewes, aged 2.5 to 5 years, non-pregnant and not lactating. A phenotypic measurement consisting of live weight and body dimensions, was taken. Samples of blood were taken for extraction of genomic DNA and PCR-SSCP based genotyping, followed by sequencing to confirm variants in amplified fragments. A novel c.198,473,337C > A SNP was found in exon 1 of the ADIPOQ gene confirming heterogeneity with genotypes AA, CC, and CA. The AA genotype differed significantly (P < 0.05) by comparison with the CA and CC genotypes concerning live body weight and body measurements. An association between productive traits and the c.198,473,337C > A SNP revealed a significant association of the A allele (odds ratio: 2.22 (95% CI: 0.94-5.30) in the additive genetic model. Sheep with the AA genotype were heavier and had larger body dimensions, implying superior production and reproduction. Further studies are required in other breeds to prove the results.
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