Abstract
Objectives:This study was conducted to determine the correlation among prolactin gene (PRG), growth differentiation factor 9 (GDF-9), and calpastatin (CAG) genes polymorphism with growth traits in Awassi lambs.Materials and Methods:Records of 779 Awassi lambs from 264 dams and 15 sires were used. The sex, type of birth (single versus twins), weight at birth, average daily gain (ADG), and the adjusted weight at 60 days of age were determined for each animal. Blood samples were collected from all lambs to determine PRG, GDF-9, and CAG polymorphism using polymerase chain reaction-Restriction fragment length polymorphism.Results:Three PRG genotypes (AA, AB, and BB) were determined with a frequency of 0.88, 0.05, and 0.07, respectively. The frequency of each allele was 0.84 and 0.16 for A and B alleles, respectively. For GDF-9, there were only two genotypes detected (AB and BB) with a frequency of 0.96 and 0.04, respectively. The frequency of each allele was 0.92 and 0.08 for A and B alleles, respectively. For CAG, two genotypes were also detected (AB and BB) with a frequency of 0.92 and 0.08, respectively. The frequency of each allele was 0.96 and 0.04 for A and B alleles, respectively. A significant (p ≤ 0.04) effect of PRG genotype on birth weight was detected but this effect was not significant on ADG and weight at weaning. There were no associations between any of the pre-weaning growth traits and GDF-9 and CAG variants.Conclusion:The results of this study show that PRG could be used to select dams with a high frequency of dystocia to reduce birth weight of newborn lambs and therefore conserve the dam’s reproductive functions and improve lamb survivability.
Highlights
Sheep are considered an important source of livelihoods in many countries in the Middle East
This study was conducted to determine the correlation among prolactin gene (PRG), growth differentiation factor 9 (GDF-9), and calpastatin (CAG) genes polymorphism with growth traits in Awassi lambs
The sex, type of birth, weight at birth, average daily gain (ADG), and the adjusted weight at 60 days of age were determined for each animal
Summary
Sheep are considered an important source of livelihoods in many countries in the Middle East. Growth performance of lambs is one of the most detrimental factors of meat production. Strong relationships have been determined between the marketing weights and different growth traits in lambs, including birth and weaning weights and average daily gain (ADG) [2,3]. Selection for these traits in the early stages of the animal’s life may result in the overall improvement of the animal’s productivity [1]. Growth traits are substantially affected by various environmental factors such as sex, type of birth (singles versus twins), dam weight, lambing year, and season [2,4]. Growth performance is under the control of many genes that can be used for selection of individual animals based on their phenotypic expression
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