Polymorphism of p53 gene codon 72 in endometrial cancer: correlation with tumor grade and histological type.

Taiebeh Kafshdooz,Morteza Ghojazadeh,Ali Dastranj Tabrizi,Ali Abdii,Jalal Gharesouran,Leila Kafshdooz,Seyyed Mojtaba Mohaddes Ardabili,Hamideh Alizadeh

doi:10.7314/apjcp.2014.15.22.9603

Taiebeh Kafshdooz, Morteza Ghojazadeh + Show 6 more

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https://doi.org/10.7314/apjcp.2014.15.22.9603

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Abstract

Endometrial cancer is the fourth most common cancer among women in developed countries. Patients with endometrial cancer may benefit from systemic chemotherapy alone or in combination with targeted therapies if the disease is clinically diagnosed prior to spread and metastasis to other organs. The aim of this study was to evaluate the prognostic role of p53 polymorphism and its correlation with tumor grade in human uterine endometrial carcinomas. A total of 75 patients with endometrial carcinomas were studied for possible mutations in exon 4 of the p53 gene using polymerase chain reaction and restricting fragment length polymorphism techniques and sequencing. In recent study, The rate of homozygote genotype of pro/pro or Arg/Arg in high grade group was higher than in comparison with low grade one. In addition samples that were undigested in RFLP, showed mutation in exone 4. Our findings showed that high grade endometrial carcinomas are highly associated with TP53 polymorphisms in comparison with low grades.

Highlights

Endometrial carcinoma is known to be a kind of heterogeneous group of tumor with variable morphology, clinical behavior, ploidy, degree of differentiation and immunogenicity etc (Dobrzycka et al, 2010; Nazik et al, 2014) and it is an important health problem that leads to mortalitiy and morbidity of women
Our findings showed that high grade endometrial carcinomas are highly associated with TP53 polymorphisms in comparison with low grades
Clinical and histopathological findings The studied population consisted of 75 women with histologically aproved endometrial carcinoma and the tumors were divided into high grade and low grade, The grade distributions of the 75 cases according to the FIGO staging system were as follows: :low grade, 20 cases; high grade 55 cases

Summary

Introduction

Endometrial carcinoma is known to be a kind of heterogeneous group of tumor with variable morphology, clinical behavior, ploidy, degree of differentiation and immunogenicity etc (Dobrzycka et al, 2010; Nazik et al, 2014) and it is an important health problem that leads to mortalitiy and morbidity of women. It is the most frequent malignant female genital tract with over 150,000 new cases diagnosed annually worldwide and the fourth most common cancer in women among industrialized countries (Levine et al, 1998; Hernandez et al, 2010). Conclusions: Our findings showed that high grade endometrial carcinomas are highly associated with TP53 polymorphisms in comparison with low grades

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