Abstract
BackgroundA few studies revealed that the polymorphisms of Mucin 1 gene have a role and significance as a susceptible factor contributing to gastric cancer. To better understand the roles of two MUC1 genotype polymorphisms of rs4072037 and rs2070803 in the development of gastric cancer in Vietnamese population, a multicenter, large-sample, case–control study was conducted to investigate the potential association of these single-nucleotide polymorphisms (SNPs) of MUC1 gene with gastric cancer risk and to evaluate the combination factors in relation with these SNPs.MethodsThis case–control study included 302 gastric cancer patients and 304 controls at four national medical hospitals between 2016 and 2018. All participants were interviewed for sociodemographic characteristics, smoking and drinking status, and personal and family history of gastric diseases. Genotyping was done using polymerase chain reaction–restriction fragment length polymorphism analysis. The association of SNPs with gastric cancer was explored using logistic regression models.ResultsAA genotype for rs4072037 was significantly associated with increased gastric cancer. Those with AA genotype had higher gastric cancer risk than had patients with AG (OR: 2.09, 95% CI: 1.48–2.96) and a combination of AG+GG (OR: 1.85, 95% CI: 1.33–2.56). In rs2070803, GG genotype increased gastric cancer risk when compared with AG (OR: 1.97, 95% CI: 1.39–2.80) and AG+AA (OR: 1.71, 95% CI: 1.23–2.39). AG genotypes in both SNPs decreased gastric cancer risk when compared with homogenous genotype, more specifically AA (OR: 0.51, 95% CI: 0.35–0.72) and GG (OR: 0.58, 95% CI: 0.35–0.97). These genotypes in combination with above-60-year-old age, male gender, alcoholism, and personal history of gastric disease were also significantly elevated risk factors for gastric cancer.Conclusionsrs4072037 and rs2070803 of Mucin 1 genes are two genotypic risk factors for gastric cancer. Those in combination with gender, family history, smoking, and drinking habits significantly increase the risk of gastric cancer.
Highlights
Gastric cancer, the fourth most common cancer worldwide and the second leading cause of cancer death, was known as a heterogeneous, multifactorial, highly malignant type of cancer [1]
Several genome-wide association studies have indicated the association between gastric cancer and single-nucleotide polymorphism (SNP) of Mucin 1 (MUC1) gene, which codes for the cell surface glycoprotein mucin-1 and is used in clinical practice settings as tumor marker C15-3, in various Asian and European populations [7, 10, 11], besides two SNPs rs4072037 and rs2070803 of MUC1 gene that were found to be associated with increased gastric cancer susceptibility
To better understand the roles of two MUC1 genotype polymorphisms of rs4072037 and rs2070803 in the development of gastric cancer in Vietnamese population, we sought to investigate the potential association of Abbreviations: MUC1, Mucin 1; SNP, single-nucleotide polymorphism; PCRRFLP, polymerase chain reaction–restriction fragment length polymorphism; Odds ratios (ORs), odds ratio; H. pylori, Helicobactor pylori; TRIM46, Tripartite Motif Containing 46; SULT1A1, Sulfotransferase Family 1A Member 1; COX-2, cyclooxygenase-2; TNF, tumor necrosis factor
Summary
The fourth most common cancer worldwide and the second leading cause of cancer death, was known as a heterogeneous, multifactorial, highly malignant type of cancer [1]. It is important that we replicate the study about MUC1 polymorphism in Vietnamese population to understand with certainty whether it has different effects on the risk of developing gastric cancer and, in turn, developing a populationspecific genetic panel for gastric cancer screening. To better understand the roles of two MUC1 genotype polymorphisms of rs4072037 and rs2070803 in the development of gastric cancer in Vietnamese population, a multicenter, large-sample, case– control study was conducted to investigate the potential association of these singlenucleotide polymorphisms (SNPs) of MUC1 gene with gastric cancer risk and to evaluate the combination factors in relation with these SNPs
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