Polymorphism of interleukin (IL)-4 receptor is associated with the risk and the prognosis of epithelial ovarian cancer in Korean women

Abstract

Objective：The aim of current investigation was to analyze the association between a single nucleotide polymorphism (SNP) in interleukin (IL)-4R Ile50Val and epithelial ovarian cancer (EOC) susceptibility and its prognosis in Korean women. Methods：The blood samples of 98 EOC patients and 321 cancer-free control subjects were collected. Polymorphisms in IL-4R Ile50Val were determined using TaqMan method. Allele frequency and genotype distribution in the EOC group were compared with those of the control group. Thereafter association between this polymorphism and clinicopathologic factors such as stromal invasion, histologic type, surgical stage, and survival within the case group was evaluated. Results：In the EOC group, the frequency of Ile allele was 52.0% which is significantly higher than that of the control group, 46.3% (p=0.014).There was significantly elevated risk of EOC in patients with Ile allele, with Odds Ratio of 2.49 (Ile/Ile+Ile/Val versus Val/Val, 95% Confidence Internal: 1.34-4.59). In subgroup analysis within the cancer group, this polymorphism showed no significant difference in clinicopathologic parameters such as stromal invasion, histologic type, and surgical stage. However the survival analysis showed the poor survival in the patients with Val/Val genotype. Conclusion：IL-4R Ile50Val polymorphism is associated with the susceptibility and the survival of EOC in Korean women.