Abstract
Background and Objectives: Inflammation plays a crucial role in the pathophysiology of ischemic stroke (IS). Interleukin-1B and interleukin-1 receptor antagonists are key factors in inflammatory processes. Aims: The aims of our study were to evaluate the relationship between genetic variation in interleukin-1B (IL1B) rs1143627 and interleukin-1 receptor antagonist (IL1RN) variable-number-tandem-repeats (VNTR), and overall IS and subtype prevalence rates. Materials and Methods: The analysis included 147 hospitalized Polish patients with IS diagnosed using conventional criteria. The control group consisted of 119 healthy subjects. Genotypes were determined by polymerase chain reaction. Results: A significant association between rs1143627 and stroke was found. The -31C IL1B polymorphism showed an association with overall IS, OR = 2.30 (1.36–3.87) p = 0.020. An association was also detected for LVI (large vessel infarction) subtypes of stroke. After risk factor adjustment (age, diabetes mellitus, dyslipidemia), the C allele was found to be an independent risk factor for LVI, OR = 1.99 (1.05–3.79) p = 0.036. Significant association was not observed between IL1RN alleles and IS. Conclusions: Our results suggest that the C allele of IL1B rs1143627 may be associated with susceptibility to overall IS and LVI subtypes of stroke in the Polish population.
Highlights
Ischemic stroke (IS) is a multifactor disease, resulting from classical and genetic risk factors and their interactions
Ischemic stroke is a disease of complex etiology, and it is generally accepted that both environmental and genetic factors play a crucial role in the development of the disease
We found no interaction between interleukin-1 receptor antagonist (IL1RN) and IL1B concerning ischemic stroke (IS) risk assuming the dominant x dominant and recessive x recessive models
Summary
Ischemic stroke (IS) is a multifactor disease, resulting from classical and genetic risk factors and their interactions. The IL1 family consists of IL1A, IL1B and one antagonist cytokine, the IL1 receptor antagonist (IL1RA) [1,2]. IL1A and IL1B are inflammatory factors produced by different cell types in response to various stimuli. They affect the endothelial cells, including the induction of adhesion molecules and prothrombotic effects, while the naturally occurring competitive IL1RA may antagonize the immune response. Inflammation plays a crucial role in the pathophysiology of ischemic stroke (IS). Interleukin-1B and interleukin-1 receptor antagonists are key factors in inflammatory processes. Aims: The aims of our study were to evaluate the relationship between genetic variation in interleukin-1B (IL1B) rs1143627 and interleukin-1 receptor antagonist (IL1RN).
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