Abstract
BackgroundRecognition of different genetic variants underlying osteoporosis would make it possible to introduce individual, symptomatic treatment as well as early prophylaxis of osteoporosis.The aim of the study was to evaluate the frequency of the rs2275913 (−197G > A) polymorphism of the IL-17 gene and assess the relation of this polymorphism with the clinical parameters of the osseous turnover and degree of the postmenopausal osteoporosis.MethodsThe study included 800 women of postmenopausal (505) and reproductive (295) ages throughout the Wielkopolska region in Poland. The postmenopausal group included women with osteoporosis and osteopenia, and those who were healthy. Women at reproductive age were healthy. The frequency of the tested gene polymorphism was evaluated in the group where bone mineral density (BMD) was marked and in the control group.ResultsThe results obtained showed that the T-score in the female population with osteopenia was remarkably lower in women showing the GG genotype of -197G > A polymorphism of IL-17 gene compared to patients with heterozygous GA genotype. It has been shown that the BMD value for L2–L4 YA in the evaluated female population with osteoporosis is significantly higher in women with the GA genotype of -197G > A polymorphism of IL-17 gene compared to women with the GG genotype (76.32% versus 59.93%, P <0.05). It has also been noted that the BMD value for L2 to L4 AM in patients with the GG genotype was lower than in women with the AA genotype (69.73% versus 80.88%, P <0.05).ConclusionsIt is suggested that the -197G > A polymorphism of the IL-17 gene may be considered as a genetic factor of postmenopausal osteoporosis. This polymorphism can influence the bone mineral density and T-score value in young women and postmenopausal women.
Highlights
Recognition of different genetic variants underlying osteoporosis would make it possible to introduce individual, symptomatic treatment as well as early prophylaxis of osteoporosis
The findings showed that the bone mineral density (BMD) value for the L2 to the L4 age matched (AM) in patients with the GG genotype was lower than in women with the AA genotype (69.73% versus 80.88%, p
The present study showed no significant changes related to the impact of the examined Interleukin 17 (IL-17) polymorphism on the development of osteoporosis
Summary
Recognition of different genetic variants underlying osteoporosis would make it possible to introduce individual, symptomatic treatment as well as early prophylaxis of osteoporosis. Interleukin 17 (IL-17) is a proinflammatory cytokine. The gene IL-17 is localized at the short arm of chromosome 6 in position 6p12, coding the 155-length protein product of amino acids. Interleukin 17A was the first cytokine of the IL-17 family to be discovered [1]. Interleukin 17E is produced mainly by Th2 cells, whereas IL-17A and IL-17 F are produced by different types of cells, including. IL-17 and cytokines involved in Th17 lymphocyte production, including IL-23 and IL-21, have been believed to play a significant role in the pathogenesis of rheumatoid arthritis. Today it is known that IL-17 produces Th17 lymphocytes and other types of cells, including macrophages, neutrophils and mast cells [2]. Interleukin 17 shows pro-destructive properties, stimulating the epithelial, endothelial and
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