Polymorphism of interleukin-1β gene and susceptibility to chronic adenoiditis development at children of Siberia

Abstract

The research objective was to establish a role of polymorphism of interleukin� 1β gene in the locus 3954 (rs 1143634) on the chromosome 2q13� 21 as a risk factor of an adverse course of the inflammatory process at chronic adenoiditis. The research is a part of the complex scientific subject “Translational Otorhinolaryngology” which was carried out in 2010�2012. The results of genotyping of 944 people were received. High total frequency of inheritance of mutant polymorphic allelic variants of interleukin�1 β gene, including homozygous (C/C) and heterozygous (С/Т) carriage is revealed at children with chronic adenoiditis. The frequency was 95. 5% in sampling. At a homozygous carriage of oligonucleotide replacement of thymine for cytosine in the position 3954 o f interleukin�1β gene functional activity of interleu kin�1β changed�