Polymorphism of HLA-A,HLA-B and DRB1 alleles and haplotypes in Chinese northern Han patients with acute leukemia and chronic myeloid leukemia

Abstract

Objective To study the polymorphism of HLA-A,B,DRB1 alleles and haplotypes in Chinese northern Han patients with AL and CML.Methods The frequencies of HLA-A,B,DRB1 alleles and haplotypes were estimated by Expectation-Maximization method based on the phenotypes of 1 270 AL patients and 803 CML patients in Chinese northern Han,and then compared by chi-square test.Results The frequent of A*02,A*03,A*24,B*37,B*38,B*44,B*45,B*46,B*50,B*51,B*52,B*54,B*60,B*65,DRB1*03,DRB1*09,DRB1*10 and DRB1*15 alleles were different with statistically significant in both AL and CML patients in Chinese northern Han.326 HLA-A-B haplotypes,357 HLA-B-DRB1 haplotypes and 1 278 HLA-A-B-DRBl haplotypes were the common haplotype in the two groups of patients.7.1%(23/326)of HLA A-B haplotypes,6.2%(22/357)of HLA-B-DRB1 haplotypes and 4.0%(51/1278)of HLA-A-B DRB1 haplotypes were different with statistically significant in the two groups of patients.Conclusion The distribution of HLA-A,B,DRB1 alleles and haplotypes has rich polymorphism and has own genetic characteristics in Chinese northern Han patients with AL and CML. Key words: Leukemia; HLA; Allele; Haplotype; Frequency