Abstract
The results of research of polymorphic loci of DNA repair system genes - XRCC1 (rs25487), XPD (rs13181), XRCC3 (rs861539) of patients with alcoholic liver disease are presented. The object of study - DNA samples (N = 82), isolated from blood leukocytes from populations of Bashkortostan Republic suffering from chronic alcoholism with manifestations of alcoholic liver disease. Polymorphic variants G28152A (Arg399Gln) of the XRCC1 gene, A35931C (Lys751Gln) of the XPD gene, C18067T (Thr241Met) of the XRCC3 gene were studied by analysis of restriction fragment length polymorphism products of polymerase chain reaction. We observed the significant increase frequencies both alcoholic liver disease genotype AC (Lys/Gln) gene XPD (OR=1,71; р=0,03) polymorphic locus, and genotype TT (Met/Met) XRCC3 gene (OR=2,46; p=0,03) polymorphic locus in hepatitis as compare to the healthy. We supposed that these genotypes may be used as genetic markers of predisposition to alcoholic hepatitis. Less susceptible to the liver disease persons with genotype AA (Lys/Lys) gene XPD (OR=0,60; р=0,04) and CT (Thr/Met) gene XRCC3 (OR=0,50; p=0,02).
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