Polymorphism in transmembrane region of MICA gene and cholelithiasis.

Abstract

To study the significance of polymorphism of MHC class I chain-related gene A (MICA) gene in patients with cholelithiasis. Subjects included 170 unrelated adults (83 males) with cholelithiasis and 245 randomly selected unrelated adults (130 males) as controls. DNA was extracted from peripheral leukocytes and analyzed for polymorphism of 5 alleles (A4, A5, A5.1, A6 and A9) of the MICA gene. There was no significant difference in phenotype, allele, and genotype frequencies of any of the 5 alleles between cholelithiasis patients and controls. This study demonstrates that MICA alleles studied bear no relation to cholelithiasis.