Abstract
The role of single nucleotide polymorphism rs10937405 (C>T) of the TP63 gene in cancer including leukemia has previously been studied in different world populations; however, the role of this variant in leukemia in the North Indian population of Jammu and Kashmir is still unknown. In the present study, we investigated the association of genetic variant rs10937405 with leukemic in the Jammu and Kashmir population. A total of 588 subjects, (188 cases and 400 controls) were recruited for the study. The rs10937405 variant was genotyped by using the real-time based TaqMan assay. A statistically significant association was observed between the rs10937405 and leukemia [OR of 1.94 (95% CI 1.51-2.48), p=1.2x10-6]. The current study concludes that the rs10937405 variant is a risk factor for the development of leukemia in the population of Jammu and Kashmir, North India. However, it would be interesting to explore the contribution of this variant in other cancers as well. Our findings will help in the development of diagnostic markers for leukemia in the studied population and potentially for other North Indian populations.
Highlights
Leukemia ranks among the top most cancers in the world with an estimated 3,00,000 new cases (2.8% of all new cancer cases and 3.8% deaths) diagnosed every year globally[1,2]
Background: The role of single nucleotide polymorphism rs10937405 (C>T) of the to p63 isoforms either containing (TP63) gene in cancer including leukemia has previously been studied in different world populations; the role of this variant in leukemia in the North Indian population of Jammu and Kashmir is still unknown
In the present study, we investigated the association of genetic variant rs10937405 with leukemic in the Jammu and Kashmir population
Summary
Leukemia ranks among the top most cancers in the world with an estimated 3,00,000 new cases (2.8% of all new cancer cases and 3.8% deaths) diagnosed every year globally[1,2]. We aimed to explore the association of variant rs10937405 of TP63 with leukemia in the North Indian population of Jammu and Kashmir. The role of single nucleotide polymorphism rs10937405 (C>T) of the TP63 gene in cancer including leukemia has previously been studied in different world populations; the role of this variant in leukemia in the North Indian population of Jammu and Kashmir is still unknown. Conclusion: The current study concludes that the rs10937405 variant is a risk factor for the development of leukemia in the population of Jammu and Kashmir, North India.
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