Polymorphism in the peroxisome proliferator-activated receptor-gamma gene in women with preeclampsia.

Abstract

To investigate peroxisome proliferator-activated receptor-gamma (PPARgamma) genotype frequencies in women with preeclampsia and elucidate its role in the pathogenesis of preeclampsia. The study involved 133 preeclamptic and 115 healthy control women who were genotyped for a known functional variant of the PPARgamma gene using single-strand conformation polymorphism (SSCP) analysis. We found no association between PPARgamma polymorphism and the occurrence of preeclampsia. In affected women, the clinical course of preeclampsia was no different among the three PPARgamma genotypes. Our data does not support a role for PPARgamma gene polymorphism in the pathogenesis of preeclampsia. Accordingly, it is unlikely that PPARgamma polymorphism influences the severity of preeclampsia. There is no association between PPARgamma polymorphism and the occurrence or severity of preeclampsia.