Polymorphism gene methylene tetra hydrofolate reductase (MTHFR) C677T and recurrence within one month end point in ischaemic stroke patients with and without hypertension

Abstract

Background The genetic mutations associated with stroke are multiple and work in combination rather than isolated genes. Although many studies have emphasized strategies for the primary prevention of stroke, the prevention of recurrent stroke has received less attention. Recurrent stroke occurs most frequently in the early period after ischaemic stroke, with estimated ranging from 1,2%–9%. Aim This study aimed to know about the association between polymorphism gene MTHFR C677T and recurrence within one month in ischaemic stroke patients with and without hypertension. Material and methods The study was conducted with the approval of the Ethic Committee of the institutions involved and written informed consent was obtained from all subjects or their relatives (for comatose patients). All sample matched with inclusion and exclusion criteria. The neurological deficits confirmed in all cases by computerized tomography (CT) scan. We chose the outcome of recurrence within one month. Results A total of 106 were recruited, comprising 53 cases ischaemic stroke with hypertension 53 cases without hypertension. We have done the PCR- RFLP to all the patients, we got 78 patients with 677CC of MTHFR genotype, 23 patients with 677CT genotype and 5 patients with 677TT genotype. The association between polymorphism gen MTHFR C677T and recurrence was not significant but we found that recurrence within one month in genotype TT was the highest (20%). Conclusion We assumed that polymorphism MTHFR C677T have an important role with recurrence in early period after ischaemic stroke.