Polymorphism A1166C of AGTR1 Gene and the State of Intrarenal Blood Flow in Patients with Essential Arterial Hypertension 1-2 Degrees

Abstract

to study relationship between genetic disorders and features of intrarenal blood flow in patients with essential arterial hypertension(AH) of 1-2 degree. We examined 100 patients (60 women, 40 men) aged 35 to 58 years with 1-2‑degree essentialarterial hypertension (AH) and chronic kidney disease (CKD) stages I-III. Examination included triplex scanning of renal arterieson the ultrasound scanner Vivid-7 Dimension, genotyping of single-nucleotide polymorphism А1166С of the AGTR1 gene by realtime polymerase chain reaction (PCR), estimation of glomerular filtration rate (GFR) using CKD-EPI formula. Patients were dividedinto 2 groups: group 1 included persons with I and II stage CKD (n=65, 25 men and 40 women), group 2 included patients with stagesIIIA and IIIB CKD (n=35, 15 men and 20 women). Among patients of group 1 prevailed genotype AA, while among group 2patients prevailed genotype AC. Speed of blood flow in interlobar renal arteries was higher in the group 1 compared with group 2, whilein the group 2 time of acceleration of blood flow was higher than in the group 1. The data obtained are indicative of the decreaseof systolic, diastolic, and averaged maximal blood flow velocity and the lengthening of acceleration time in patients with higherCKD stage. The presence in the genotype of patients with 1-2‑degree AH of AGTR1 1166С allele may be considered a riskfactor of early development of CKD. Lowering of speed characteristics of blood flow and lengthening of the acceleration time in patientswith AH can be a criterion of hypertensive nephropathy development.