Year-end Sale % OFF 
Abstract
Colorectal cancer is the third-most-prevalent form of cancer in the world. Several studies report that prostaglandins are mediators of carcinogenesis. Cyclooxygenase, also known as prostaglandin endoperoxidase H synthase, is a pro-inflammatory enzyme that intercedes in the formation of eicosanoids from arachidonic acid. Polymorphisms in the COX-2 gene have been associated with increased risk of different tumors, including colorectal. Genetic variations in COX-2 may affect enzyme activity or expression, thereby altering the production of prostaglandins and potentially modulating an individual’s inflammatory response and risk of colorectal cancer. A functional polymorphism in the COX-2 promoter region (–765G>C), located at a putative stimulatory protein-1 (SP1) binding site, suggests the involvement of a complex array of factors regulating its expression. This study was designed to evaluate the status of –765G>C polymorphism (rs20417) and risk of sporadic colorectal cancer in an Iranian population.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
