Polymorphism (353)R>Q of gene of blood clotting factor VII and plasma hemostasis

Abstract

A comparative estimation was conducted to assess the prevalence of genotypes and alleles of the (353)R>Q polymorphism of the coagulation factor FVII gene between a group of the Russian adolescents with essential arterial hypertension and a group of Russian adolescents without such health problems. The RR genotype was diagnosed in 55 adolescents (75.34%) of the control group and in 99 adolescents (84.61%) of the adolescents suffering from essential arterial hypertension (χ2 = 1.949, p = 0.163). The frequency of the R-allel was 85% and 91.9%, respectively (χ2 = 3.110, p = 0.078). The role of the FVII gene in the determination of the F7 plasma activity was defined in adolescents with essential arterial hypertension and holders of different alleles. Holders of the R allele had significantly higher activity of coagulation factor F7 (97.66 ± 15.48 against 83.37 ± 15.16, p = 0.002) and factor F2 (107.45 ± 6.03 against 103.75 ± 6.81, p = 0.023) than holders of the Q allele. This relationship was not found in adolescents of the control group.