Abstract
Summary. A distribution of alleles and genotypes of chemokine receptor CCR5 gene and constitutional and morphological phenotypes of asthma patients and their relatives in comparison with healthy persons have been studied. Findings of 62 Russian families of patients with asthma (n = 232) living in Krasnoyarsk city were used in this study. The polymorphism of a coding region of chemokine receptor CCR5 gene was associated with allergic asthma and also was an important component of congenital susceptibility for asthma. In patients with asthma, most relationships were associated with fat body mass. Given an identified association between asthma and genotype II of CCR5 gene there could be a consideration that fat dismorphism could contribute to gene polymorphism responsible for the development of allergic asthma.
Highlights
in Krasnoyarsk city were used in this study
The polymorphism of a coding region of chemokine receptor CCR5 gene was associated with allergic asth ma
most relationships were associated with fat body mass
Summary
И.И.Черкашина 1, С.Ю.Никулина 1, Н.И.Логвиненко 2, В.Н.Максимов 3, М.И.Воевода 3, В.А.Шульман 1, В.А.Шестовицкий 1, В.А.Чупахина 1, А.А.Чернова 1, А.В.Талаевская 4. 1 – ГОУ ВПО "Красноярский государственный медицинский университет" им. Партизана Железняка, 1; 2 – ГБОУ ВПО "Новосибирский государственный медицинский университет" Минздрава России: 630091, Новосибирск, Красный проспект, 52; 3 – УРАМН ФГБУ "НИИ терапии" Сибирского отделения РАМН: 630089, Новосибирск, ул. Бориса Богаткова, 175 / 1; 4 – МБУЗ Городская поликлиника No 6: 660013, Красноярск, ул. I.I.Cherkashina, S.Yu.Nikulina, N.I.Logvinenko, V.N.Maksimov, M.I.Voevoda, V.A.Shulman, V.A.Shestovitsky, V.A.Chupakhina, A.A.Chernova, A.V.Talaevskaya
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