Abstract
The most common facial malformation in all populations and ethnic groups is Cleft lip and palate (CB/L). Various factors cause nonsyndromic cleft lip and palate abnormalities (CB/L NS) such as interactions between environmental and genetic factors, so that CB/L embryopathy is not clear. Deficiency of Zn with certain severity in pregnant women can be a risk factor for CB/L. The purpose of this study was to analyze the relationship of polymorphism of rs7526700, rs2278651, and rs611386 of the gene SCL30A1 mother with a group of deficiency events of Zinc maternal. The type of this research is an observational study through cross sectional approach with the research subjects are mothers and newborns diagnosed with CB/L NS in the Perinatology Department of Dr. Hasan Sadikin Hospital Bandung and other Network Hospitals. The research was conducted in September 2016 to June 2017 with 34 groups samples. Data were analyzed using fisher’s exact test and correlation test. The results showed that the majority of mothers who became the research respondents aged 25-29 years were 34% and the majority of infants who became the respondents were female as much as 60%, and most types of lip and palate disorders experienced by infants who became the respondents was Unilateral CB/L which is as much as 66%. Furthermore, the results of statistical tests indicated that there was no significant relationship between polymorphism of rs7526700, rs2278651, and rs611386SLC30A1 maternal gene with levels of Zinc maternal
Highlights
Most common facial malformations in all populations and ethnic groups are the cleft lip and palate (CB/L) reported from all anomalies in the head and neck around 65%
This research was an observational study with a cross sectional approach in which the research subjects are mothers and newborns diagnosed with CB/L NS in the Perinatology Department of Dr Hasan Sadikin Hospital Bandung and the Network Hospital, among others: RSUD of Bandung City of Ujung Berung, Cibabat City Hospital of Cimahi, Special Hospital for Women and Children in Bandung City, and those who came to the Foundation for Lip and Palate Disease Foundation (YPPCBL) Bandung conducted in September 2016 to June 2017
The research subjects were selected based on inclusion criteria including new mothers who gave birth to babies diagnosed with CB/L NS, newborns diagnosed with CB/L NS, mothers and babies diagnosed with CB/L NS from the Deutero Melayu tribe, as well as mothers and babies diagnosed with CB/L NS who were in good health and good general condition, selected through consecutively Sampling
Summary
Most common facial malformations in all populations and ethnic groups are the cleft lip and palate (CB/L) reported from all anomalies in the head and neck around 65%. Failed unification of central facial skeleton part in the fourth to the tenth week of pregnancy is the cause of cleft lip and palate since the embryo experiences development and growth of facial skeleton at the end of the fourth week and the end of the eighth week of pregnancy. The process of fusion of the palate ends at the end of the tenth week of pregnancy.[3,4]. Various factors cause nonsyndromic cleft lip and palate abnormalities (CB/L NS) such as interactions between environmental and genetic factors so that CB/L of the embryopathy is not clear.[4] Both have complex
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