Abstract
Background The cytochrome P450 2C9 and 3A5 enzymes are predominantly found in the human liver, and have important functions in the metabolism of antiepileptics. Genetic polymorphisms in these genes are associated with altered enzymatic activities and may give rise to the risk of drug hypersensitivity. Therefore, we analyze the association between CBZ hypersensitivity reactions (CHR) and polymorphisms of CYP2C9 and 3A5 in a population of Sao Paulo, Brazil. Methods Case-control study in which we genotyped the SNP of CYP2C9 (rs1057910, rs1799853) and 3A5 (rs776746) of samples obtained from 52 subjects with varying severities CHR, 82 tolerants, and 366 control subjects, all from Sao Paulo, Brazil. According to the alleles presente, each subject was classified as normal, decrease or increased funcion for the enzyme. The phenotype was evaluated based on standardized scoring systems using an adapted ENDA (European Network of Drug Allergy) questionnaire, medical records and on the clinical follow-up. The patch test with the culprit drug was performed according the ENDA recommendations.
Highlights
The cytochrome P450 2C9 and 3A5 enzymes are predominantly found in the human liver, and have important functions in the metabolism of antiepileptics
We analyze the association between CBZ hypersensitivity reactions (CHR) and polymorphisms of CYP2C9 and 3A5 in a population of São Paulo, Brazil
Based on the association of the polymorphism of CYP3A5 and the tolerant group, we hypothesize that it can contribute to the tolerability of anti-epileptics
Summary
Polymorfism Of CYP2C9 And 3A5 and carbamazepine hypersensitivity reactions in Brazilian subjects. Luciana Tanno1*, Daniel Kerr, Bernardo Santos, Leda Talib, Helcio Rodrigues, Wagner Gattaz, Jorge Kalil. From 6th Drug Hypersensitivity Meeting (DHM 6) Bern, Switzerland. From 6th Drug Hypersensitivity Meeting (DHM 6) Bern, Switzerland. 9-12 April 2014
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