Abstract
Investigators from the Boston Children's Hospital, New York University, Brown University, and Birmingham School of Medicine, AL, studied the clinical epilepsy and imaging features of 87 patients with polymicrogyria (PMG) and epilepsy, recruited through the Epilepsy Phenome/Genome Project.
Highlights
Of 13 deaths related to seizures 10 (77%) were attributed to SUDEP
The higher mortality rates reported in this cohort are related to duration of follow-up, most of the mortality beginning in adolescence and years after the onset of epilepsy
Generalized PMG presented with an earlier age of seizure onset and an increased prevalence of developmental delay prior to seizure onset (57.1%)
Summary
Of 13 deaths related to seizures (almost 20% of all deaths in this combined cohort of new-onset childhood epilepsies) 10 (77%) were attributed to SUDEP. The higher mortality rates reported in this cohort are related to duration of follow-up, most of the mortality beginning in adolescence and years after the onset of epilepsy Investigators from the Boston Children’s Hospital, New York University, Brown University, and Birmingham School of Medicine, AL, studied the clinical epilepsy and imaging features of 87 patients with polymicrogyria (PMG) and epilepsy, recruited through the Epilepsy Phenome/Genome Project.
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