Polymicrobial sepsis models: CLP versus CASP

Abstract

Sepsis is a disease syndrome covering many different aspects of the host immune system. Our understanding of sepsis is still incomplete. Several animal models of sepsis have been developed and much of our current knowledge on the molecular basis of the disease has originated from these models. Two of the most reliable and clinically relevant rodent models to mimic human sepsis in the animal model are cecal ligation and puncture (CLP) and colon ascendens stent peritonitis (CASP).