Abstract
Due to the inability to dose glucocorticoid receptor modulators (GRMs) chronically as a result of their unwanted side effects, the use of polymers, nano particle and antibody drug-conjugates have been explored as targeting moieties for GRM payloads with a view to minimizing the systemic exposure of the therapeutically active GRM. This chapter discusses the many targeting modalities that include approaches for targeting specific organs like the kidney with C21 peptide analogues of dexamethasone, hydrazone analogues of the C3 carbonyl to enable localized pH dependent delivery of the therapeutically active GRM and α-TNF antibody drug conjugates with a GRM payload to target immune cells.
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