Abstract
Isotherms have been determined for the in vitro sorption of cholate and glycocholate bile salt anions by cholestyramine, under various conditions of buffer and temperature. It is shown that a change in the counter-ion of the resin, from chloride to iodide, generally results in decreased sorption. Arguments based on Donnan concepts are developed to show that the binding involves ion exchange that is accompanied by the aggregation of bile salt anions within the resin phase. The derived binding constant is found to be concentration dependent, suggesting the importance of such cooperative effects.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
