Abstract
Several polymeric materials were prepared for evaluation as potential enteric and sustained-release coatings. Three methods were used to prepare some aliphatic partial esters of copolymers of maleic anhydride with ethylene or vinyl methyl ether. Infrared and electrometric titration techniques were employed for identification and characterization of the raw material and the resultant esters. The physical data presented demonstrate relative differences in solubility and related parameters due to modification of ester chain length and degree of esterification. The relationship of ester chain length and degree of esterification is direct for dissolution pH and inverse for moisture diffusion rate, moisture sorption, and water miscibility. No significant evidence of thermal instability was found after aging at 50°. Preliminary toxicological investigations indicate that these compounds are nontoxic.
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