Abstract
This manuscript aims to provide the latest update on polymeric nanoparticle drug delivery system for breast cancer treatment after 2015 and how research-oriented it is based on the available research data. Therefore, the authors have chosen breast cancer which is the most frequent and common reason for mortality in women worldwide. The first-line treatment for breast cancer treatment is chemotherapy, apart from surgery, radiation and hormonal therapy. Chemotherapy is associated with lesser therapeutics and undesirable side effects and hence. In addition, drug resistance affects the therapeutic dose to the target site. Although various nano-based formulations have been developed for effective treatment, the polymeric nanoparticles effectively avoid the lacunae of conventional chemotherapy. There has been an effort made to understand the chemotherapy drugs and their conventional formulation-related problems for better targeting and effective drug delivery for breast cancer treatment. Thus, the polymeric nanoparticles as a strategy overcome the associated problems with resulting dose reduction, enhanced bioavailability, reduced side effects, etc. This present review has compiled the research reports published from 2015 to 2021 from different databases, such as PubMed, Google Scholar, ScienceDirect, which are related to breast cancer treatment in which the drug delivery of numerous chemotherapeutic agents alone or in combination, including phytoconstituents formulated into various polymer-based nanoparticles.
Highlights
Nowadays, the disease state of cancer is still a considerable problem worldwide
The present review summarized the various chemotherapeutic drugs and their combination formulated in polymeric nanoparticles for the promising and effective drug delivery for breast cancer treatment
Sometimes the properties of the drug may compromise and overcome the properties to gain maximum benefits in respect of therapeutic values they formulated into nanotechnology drug delivery approaches, which could be better as compared to conventional therapy
Summary
The disease state of cancer is still a considerable problem worldwide. Over1.8 million new cases and 0.6 million cancer deaths were estimated in the United States in 2020 [1]. The disease state of cancer is still a considerable problem worldwide. Chemotherapy has lots of problems such as enhanced systemic side effects, low ability to penetrate the tumor and low pharmacokinetic values. Most of the phytoconstituents have solubility and stability issues which need to be a high dose to achieve the therapeutic values [3]. To overcome these hurdles of chemotherapy and phytoconstituents, the application of nanotechnology for breast cancer treatment which makes them more efficient and successful treatment with reduced side effects has been widely researched [4]. The application makes them excellent drug carriers for photothermal therapy, photodynamic, immunotherapy, as well as chemotherapy [5]
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